Application of liquid chromatography-tandem mass spectrometry to the analysis of benzodiazepines in blood

被引：17
|
作者：
Rivera, HM
Walker, GS
Sims, DN
Stockham, PC
机构：
[1] Univ Adelaide, Sch Chem Phys & Earth Sci, Adelaide, SA 5001, Australia
[2] Forens Sci SA, Adelaide, SA 5000, Australia
来源：
EUROPEAN JOURNAL OF MASS SPECTROMETRY | 2003年 / 9卷 / 06期
关键词：
forensic toxicology; HPLC/MS/MS; ion trap; benzodiazepines; blood;
D O I：
10.1255/ejms.573
中图分类号：
O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号：
070203 ; 070304 ; 081704 ; 1406 ;
摘要：
A sensitive and selective high-performance liquid chromatography/atmospheric pressure chemical ionisation tandem mass spectrometry (HPLC/APCI-MS/MS) method for the simultaneous detection of 18 benzodiazepines and metabolites in human blood is described. The procedure utilises butyl chloride extraction at alkaline pH followed by reversed-phase liquid chromatography. The technique is suitable for screening analyses and confirmation of identity of the benzodiazepines at their lowest reported therapeutic concentrations using 500 muL of blood. The method has been successfully applied in forensic cases involving low concentrations of benzodiazepines.
引用
收藏
页码：599 / 607
页数：9
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