Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor Xa inhibitors

被引：16
|
作者：
Mohan, R [1 ]
Yun, WY [1 ]
Buckman, BO [1 ]
Liang, A [1 ]
Trinh, L [1 ]
Morrissey, MM [1 ]
机构：
[1] Berlex Biosci, Pharmaceut Discovery, Richmond, CA 94804 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 14期
关键词：
D O I：
10.1016/S0960-894X(98)00333-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An arylamidine linker has been employed for the solid-phase synthesis of N-substituted amidinoaryloxypyridine analogs 2 via nucleophilic substitution on a fluoropyridyl template. Two novel N-substituted amidinoaryloxypyridine derivatives 2a and 2b were discovered via this approach. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1877 / 1882
页数：6
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