Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor Xa inhibitors

被引：16

作者：

Mohan, R ^{[1
]}

Yun, WY ^{[1
]}

Buckman, BO ^{[1
]}

Liang, A ^{[1
]}

Trinh, L ^{[1
]}

Morrissey, MM ^{[1
]}

机构：

[1] Berlex Biosci, Pharmaceut Discovery, Richmond, CA 94804 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(98)00333-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An arylamidine linker has been employed for the solid-phase synthesis of N-substituted amidinoaryloxypyridine analogs 2 via nucleophilic substitution on a fluoropyridyl template. Two novel N-substituted amidinoaryloxypyridine derivatives 2a and 2b were discovered via this approach. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1877 / 1882

页数：6

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