The Effect of Quinapril Treatment on Insulin Resistance, Leptin and High Sensitive C-Reactive Protein in Hypertensive Patients

被引：4
|
作者：
Sari, Funda [3 ]
Eray, Esin [2 ]
Sari, Ramazan [1 ]
机构：
[1] Akdeniz Univ, Sch Med, Dept Internal Med, TR-07070 Antalya, Turkey
[2] Antalya Educ & Res Hosp, Div Endocrinol, Minist Hlth, Antalya, Turkey
[3] Antalya Educ & Res Hosp, Div Nephrol, Minist Hlth, Antalya, Turkey
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION | 2011年 / 33卷 / 08期
关键词：
hypertension; insulin resistance; high sensitive C-reactive protein; leptin; angiotensin converting enzyme inhibitors; SYMPATHETIC-NERVOUS-SYSTEM; ANGIOTENSIN-II; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; PLASMA LEPTIN; INFLAMMATION; LOSARTAN; OBESITY; RATS;
D O I：
10.3109/10641963.2011.577481
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of the study was to evaluate the effect of quinapril on HOMA-IR, high sensitive C-reactive protein and leptin. Total 54 hypertensive and 24 control subjects were included in this study. Blood pressure, leptin, high sensitive C-reactive protein, and HOMA-IR were determined at baseline and after 3 months quinapril treatment. After treatment with quinapril HOMA-IR (p = 0.04), high sensitive C-reactive protein (p = 0.027), and leptin (p = 0.046) were decreased in hypertensive patients. Quinapril may be used as a therapy for improving blood pressure as well as the insulin resistant, hyperleptinemic, and low-grade inflammatory state in hypertension.
引用
收藏
页码：548 / 551
页数：4
相关论文
共 50 条
  • [31] C-reactive protein, atherosclerosis and kidney function in hypertensive patients
    M J Hommels
    A J A M van der Ven
    A A Kroon
    A G H Kessels
    M P van Dieijen-Visser
    J A M van Engelshoven
    C A Bruggeman
    P W de Leeuw
    Journal of Human Hypertension, 2005, 19 : 521 - 526
  • [32] C-reactive protein, atherosclerosis and kidney function in hypertensive patients
    Hommels, MJ
    Van der Ven, AJAM
    Kroon, AA
    Kessels, AGH
    Van Dieijen-Visser, MP
    Van Engelshoven, JAM
    Bruggeman, CA
    de Leeuw, PW
    JOURNAL OF HYPERTENSION, 2003, 21 : S8 - S8
  • [33] Effects of febuxostat on insulin resistance and expression of high-sensitivity C-reactive protein in patients with primary gout
    Juan Meng
    Yanchun Li
    Xiaoxu Yuan
    Yuewu Lu
    Rheumatology International, 2017, 37 : 299 - 303
  • [34] Effects of febuxostat on insulin resistance and expression of high-sensitivity C-reactive protein in patients with primary gout
    Meng, Juan
    Li, Yanchun
    Yuan, Xiaoxu
    Lu, Yuewu
    RHEUMATOLOGY INTERNATIONAL, 2017, 37 (02) : 299 - 303
  • [35] Association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea
    Kapsimalis, Fotis
    Varouchakis, George
    Manousaki, Asimina
    Daskas, Spiros
    Nikita, Dimitra
    Kryger, Meir
    Gourgoulianis, Konstantinos
    LUNG, 2008, 186 (04) : 209 - 217
  • [36] Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea
    Fotis Kapsimalis
    George Varouchakis
    Asimina Manousaki
    Spiros Daskas
    Dimitra Nikita
    Meir Kryger
    Konstantinos Gourgoulianis
    Lung, 2008, 186 : 209 - 217
  • [37] Epidemiological evidence against a role for C-reactive protein causing leptin resistance
    Rutter, M. K.
    Sattar, N.
    Tajar, A.
    O'Neill, T. W.
    Lee, D. M.
    Bartfai, G.
    Boonen, S.
    Casanueva, F. F.
    Finn, J. D.
    Forti, G.
    Giwercman, A.
    Han, T. S.
    Huhtaniemi, I. T.
    Kula, K.
    Lean, M. E. J.
    Pendleton, N.
    Punab, M.
    Silman, A. J.
    Vanderschueren, D.
    Lowe, G.
    O'Rahilly, S.
    Morris, R. W.
    Wu, F. C.
    Wannamethee, S. G.
    EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2013, 168 (01) : 101 - 106
  • [38] THE EFFECT OF EXERCISE INTENSITY ON SERUM LEPTIN AND C-REACTIVE PROTEIN LEVELS
    Tsao, Te-Hung
    Hsu, Chin-Hsing
    Yang, Chang-Bin
    Liou, Tzi-Li
    JOURNAL OF EXERCISE SCIENCE & FITNESS, 2009, 7 (02) : 98 - 103
  • [39] High C-reactive protein is a strong predictor of resistance to erythropoietin in hemodialysis patients
    Barany, P
    Divino, JC
    Bergstrom, J
    AMERICAN JOURNAL OF KIDNEY DISEASES, 1997, 29 (04) : 565 - 568
  • [40] High-sensitive C-reactive protein in primary aldosteronism
    Tanemoto, Masayuki
    JOURNAL OF HYPERTENSION, 2017, 35 (01) : 200 - 201
12345