The Effect of Quinapril Treatment on Insulin Resistance, Leptin and High Sensitive C-Reactive Protein in Hypertensive Patients

被引：4

作者：

Sari, Funda ^{[3
]}

Eray, Esin ^{[2
]}

Sari, Ramazan ^{[1
]}

机构：

[1] Akdeniz Univ, Sch Med, Dept Internal Med, TR-07070 Antalya, Turkey

[2] Antalya Educ & Res Hosp, Div Endocrinol, Minist Hlth, Antalya, Turkey

[3] Antalya Educ & Res Hosp, Div Nephrol, Minist Hlth, Antalya, Turkey

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2011年 / 33卷 / 08期

关键词：

hypertension; insulin resistance; high sensitive C-reactive protein; leptin; angiotensin converting enzyme inhibitors; SYMPATHETIC-NERVOUS-SYSTEM; ANGIOTENSIN-II; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; PLASMA LEPTIN; INFLAMMATION; LOSARTAN; OBESITY; RATS;

D O I：

10.3109/10641963.2011.577481

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the study was to evaluate the effect of quinapril on HOMA-IR, high sensitive C-reactive protein and leptin. Total 54 hypertensive and 24 control subjects were included in this study. Blood pressure, leptin, high sensitive C-reactive protein, and HOMA-IR were determined at baseline and after 3 months quinapril treatment. After treatment with quinapril HOMA-IR (p = 0.04), high sensitive C-reactive protein (p = 0.027), and leptin (p = 0.046) were decreased in hypertensive patients. Quinapril may be used as a therapy for improving blood pressure as well as the insulin resistant, hyperleptinemic, and low-grade inflammatory state in hypertension.

引用

页码：548 / 551

页数：4

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