Inhibition of calcium influx during hypoxia/reoxygenation in primary cultured rat hepatocytes

被引：11
|
作者：
Crenesse, D
Hugues, M
Ferre, C
Poiree, JC
Benoliel, J
Dolisi, C
Gugenheim, J
机构：
[1] Fac Med Nice, Physiol Lab, F-06107 Nice 2, France
[2] Univ Bordeaux 2, UFR Pharm, Lab Physiol Cellulaire & Pharmacol Mol, CNRS ESA 5017, F-33076 Bordeaux, France
[3] Fac Med Nice, Chirurg Expt Lab, Nice, France
[4] Fac Med Nice, Biochim Lab, Nice, France
[5] Fac Med Nice, Biophys Lab, Nice, France
来源：
PHARMACOLOGY | 1999年 / 58卷 / 03期
关键词：
calcium influx; hypoxia/reoxygenation; hepatocytes; rat;
D O I：
10.1159/000028278
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Calcium has been demonstrated to play an important role in hepatocyte damage during ischemia/reperfusion phases. Calcium influx was determined in primary cultured rat hepatocytes submitted to a succession of warm hypoxia and reoxygenation phases in the presence of diltiazem, gallopamil and a Na+/ H+ antiport inhibitor, HOE-694:. Only diltiazem significantly inhibited calcium influx with higher potency after reoxygenation than after hypoxia only, suggesting a complex mechanism of action of diltiazem which could act on different physiological functions involved in Ca2+ invasion of hepatocytes after hypoxic insult.
引用
收藏
页码：160 / 170
页数：11
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