Inhibition of calcium influx during hypoxia/reoxygenation in primary cultured rat hepatocytes

被引：11

作者：

Crenesse, D

Hugues, M

Ferre, C

Poiree, JC

Benoliel, J

Dolisi, C

Gugenheim, J

机构：

[1] Fac Med Nice, Physiol Lab, F-06107 Nice 2, France

[2] Univ Bordeaux 2, UFR Pharm, Lab Physiol Cellulaire & Pharmacol Mol, CNRS ESA 5017, F-33076 Bordeaux, France

[3] Fac Med Nice, Chirurg Expt Lab, Nice, France

[4] Fac Med Nice, Biochim Lab, Nice, France

[5] Fac Med Nice, Biophys Lab, Nice, France

来源：

PHARMACOLOGY | 1999年 / 58卷 / 03期

关键词：

calcium influx; hypoxia/reoxygenation; hepatocytes; rat;

D O I：

10.1159/000028278

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Calcium has been demonstrated to play an important role in hepatocyte damage during ischemia/reperfusion phases. Calcium influx was determined in primary cultured rat hepatocytes submitted to a succession of warm hypoxia and reoxygenation phases in the presence of diltiazem, gallopamil and a Na+/ H+ antiport inhibitor, HOE-694:. Only diltiazem significantly inhibited calcium influx with higher potency after reoxygenation than after hypoxia only, suggesting a complex mechanism of action of diltiazem which could act on different physiological functions involved in Ca2+ invasion of hepatocytes after hypoxic insult.

引用

页码：160 / 170

页数：11

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