Dipeptide-functionalized MIL-101(Fe) as efficient material for ibuprofen delivery

被引：12
|
作者：
Asadi, Fatemeh Rajab [1 ]
Hamzavi, Seyedeh Fazileh [2 ]
Shahverdizadeh, Gholam Hossein [3 ]
Ilkhchi, Mahdi Ghasedi [3 ]
Hosseinzadeh-Khanmiri, Rahim [3 ]
机构：
[1] Shahid Beheshti Univ, Dept Phys, Tehran, Iran
[2] Islamic Azad Univ, Sci & Res Branch, Dept Marine Biol, Tehran, Iran
[3] Islamic Azad Univ, Tabriz Branch, Dept Chem, Tabriz, Iran
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2018年 / 32卷 / 12期
关键词：
characterization; dipeptide; functionalization; ibuprofen delivery; MIL-101(Fe); METAL-ORGANIC-FRAMEWORK; DRUG-DELIVERY; MESOPOROUS SILICA; NANOPARTICLES; ADSORPTION; MOF; COMPOSITES; CATALYST; RELEASE; CARBON;
D O I：
10.1002/aoc.4552
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two derivatives of a dipeptide-functionalized metal-organic framework were synthesized through isocyanide-based multi-component reactions from amine-containing MIL-101(Fe). The functionalized materials were characterized by means of Fourier transform infrared spectroscopy, X-ray diffraction Brunauer-Emmett-Teller measurements, thermogravimetric analysis, elemental analysis and scanning electron microscopy. The performances of these functionalized MIL-101(Fe) materials with different functions were evaluated for ibuprofen delivery during six days, showing a good ability for adsorption of significant content of the drug and very slow release.
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页数：6
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