Functional characterization of chicken cytokines homologous to mammalian IL-15 and IL-2

被引：0
|
作者：
Lillehoj, HS [1 ]
Min, WG [1 ]
Choi, KD [1 ]
Babu, US [1 ]
Burnside, J [1 ]
Miyamoto, T [1 ]
Lillehoj, EP [1 ]
机构：
[1] USDA ARS, Beltsville Agr Res Ctr, Livestock & Poultry Sci Inst, Beltsville, MD 20705 USA
来源：
CURRENT PROGRESS ON AVIAN IMMUNOLOGY RESEARCH, PROCEEDINGS | 2001年
关键词：
chickens; cytokines; interleukin-2; interleukin-15; NK cells;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Full-length cDNA encoding chicken IL-15 was cloned from chicken liver cDNA library and its functional characteristics were compared to chicken IL-2. Both recombinant IL-2 and IL-15 stimulated the growth of T cells and enhanced the activity NK-cells in vitro. Subcutaneous injection of chickens with IL-2 genes increased the percentages of CD3+, CD4+, CD8+, gammadelta T, and alphabeta T lymphocytes. In contrast, injection of chickens with IL-15 gene preferentially enhanced CD3+ T lymphocytes. Collectively, these results indicate that chicken IL-15 and IL-2 represent T cell growth factors and these cytokines enhance host immunity mediated by T and NK cells.
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页码：8 / 13
页数：6
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