Functional characterization of chicken cytokines homologous to mammalian IL-15 and IL-2

被引：0

作者：

Lillehoj, HS ^{[1
]}

Min, WG ^{[1
]}

Choi, KD ^{[1
]}

Babu, US ^{[1
]}

Burnside, J ^{[1
]}

Miyamoto, T ^{[1
]}

Lillehoj, EP ^{[1
]}

机构：

[1] USDA ARS, Beltsville Agr Res Ctr, Livestock & Poultry Sci Inst, Beltsville, MD 20705 USA

来源：

CURRENT PROGRESS ON AVIAN IMMUNOLOGY RESEARCH, PROCEEDINGS | 2001年

关键词：

chickens; cytokines; interleukin-2; interleukin-15; NK cells;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Full-length cDNA encoding chicken IL-15 was cloned from chicken liver cDNA library and its functional characteristics were compared to chicken IL-2. Both recombinant IL-2 and IL-15 stimulated the growth of T cells and enhanced the activity NK-cells in vitro. Subcutaneous injection of chickens with IL-2 genes increased the percentages of CD3+, CD4+, CD8+, gammadelta T, and alphabeta T lymphocytes. In contrast, injection of chickens with IL-15 gene preferentially enhanced CD3+ T lymphocytes. Collectively, these results indicate that chicken IL-15 and IL-2 represent T cell growth factors and these cytokines enhance host immunity mediated by T and NK cells.

引用

页码：8 / 13

页数：6

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