The Role of Canonical WNT Signaling Pathway in Oral Carcinogenesis: A Comprehensive Review

被引：0

作者：

Noguti, Juliana ^{[2
]}

Gomes De Moura, Carolina Foot ^{[2
]}

Hossaka, Thais Ayako ^{[2
]}

Franco, Marcello ^{[2
]}

Fujiyama Oshima, Celina Tijuko ^{[2
]}

Dedivitis, Rogerio Aparectdo ^{[3
]}

Ribeiro, Daniel Araki ^{[1
,2
]}

机构：

[1] Univ Fed Sao Paulo, Dept Biosci, BR-11060001 Santos, SP, Brazil

[2] Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, Brazil

[3] Ana Costa Hosp & Santa Casa Misericordia Santos, Dept Head & Neck Surg, Santos, Brazil

来源：

ANTICANCER RESEARCH | 2012年 / 32卷 / 03期

关键词：

WNT; oral cancer; apoptosis; review; BETA-CATENIN EXPRESSION; SQUAMOUS-CELL CARCINOMA; MAMMARY ONCOGENE INT-1; RAT TONGUE; CLINICOPATHOLOGICAL FEATURES; FRIZZLED RECEPTORS; GENE-MUTATIONS; BCL-2; FAMILY; E-CADHERIN; APC GENE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oral cancer is a common neoplasm worldwide. The incidence and mortality have also increased in recent decades. It is characterized by poor prognosis and a low survival rate despite sophisticated surgical and radiotherapeutic modalities. The WNTs comprise a large family of highly conserved growth factors associated with a number of functions. In this review, we focus largely on the canonical pathway, revealing the recent findings, in oral cancer research, thereby raising our understanding of the mechanisms of this crucial signaling in several cellular activities.

引用

页码：873 / 878

页数：6

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