Role of Wnt canonical pathway in hematological malignancies

被引：0
|
作者：
Xueling GE
Xin Wang
机构：
[1] Provincial Hospital Affiliated to Shandong University,Department of Hematology
来源：
Journal of Hematology & Oncology | / 3卷
关键词：
Acute Myeloid Leukemia; Chronic Lymphocytic Leukemia; Chronic Myeloid Leukemia; Adenomatous Polyposis Coli; Mantle Cell Lymphoma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the pathogenesis of many carcinomas. Moreover, Wnt/β-catenin pathway has been revealed to be associated with angiogenesis. Wnt canonical pathway signaling has great potential as a therapeutic target. It has been disclosed that some hematological malignancies, such as chronic lymphocytic leukemia, mantle cell lymphoma, may occur partly due to the constitutive activation of Wnt canonical signaling pathway. This review will summarize the latest development in Wnt canonical signaling pathway and its roles in tumorigenesis and angiogenesis.
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