Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults

被引:3
|
作者
Montesino-Goicolea, Soamy [1 ,2 ,3 ]
Valdes-Hernandez, Pedro A. [1 ,2 ,3 ]
Cruz-Almeida, Yenisel [1 ,2 ,3 ,4 ,5 ,6 ]
机构
[1] Univ Florida, Dept Community Dent & Behav Sci, Gainesville, FL 32610 USA
[2] Univ Florida, Pain Res & Intervent Ctr Excellence, Gainesville, FL 32610 USA
[3] Univ Florida, Evelyn F & William L McKnight Brain Inst, Gainesville, FL 32610 USA
[4] Univ Florida, Inst Aging, Gainesville, FL 32610 USA
[5] Univ Florida, Ctr Cognit Aging & Memory, Gainesville, FL 32610 USA
[6] Univ Florida, Dept Neurosci, Coll Med, Gainesville, FL 32610 USA
来源
PAIN RESEARCH & MANAGEMENT | 2022年 / 2022卷
基金
美国国家科学基金会;
关键词
DIFFEOMORPHIC IMAGE REGISTRATION; PRIMARY INSOMNIA; CAUDATE-NUCLEUS; HUMAN STRIATUM; BASAL GANGLIA; DEFAULT MODE; MOTOR AREAS; PREVALENCE; NETWORKS; AGE;
D O I
10.1155/2022/4347759
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Aging is associated with poor sleep quality and greater chronic pain prevalence, with age-related changes in brain function as potential underlying mechanisms. Objective. The following cross-sectional study aimed to determine whether self-reported chronic musculoskeletal pain in community-dwelling older adults moderates the association between sleep quality and resting state functional brain connectivity (rsFC). Methods. Community-dwelling older individuals (mean age = 73.29 years) part of the NEPAL study who completed the Pittsburg Sleep Quality Index (PSQI) and a rsFC scan were included (n = 48) in the present investigation. To that end, we tested the effect of chronic pain-by-PSQI interaction on rsFC among atlas-based brain regions-of-interest, controlling for age and sex. Results and Discussion. A significant network connecting the bilateral putamen and left caudate with bilateral precentral gyrus, postcentral gyrus, and juxtapositional lobule cortex, survived global multiple comparisons (FDR; q < 0.05) and threshold-free network-based-statistics. Greater PSQI scores were significantly associated with greater dorsostriatal-sensorimotor rsFC in the no-pain group, suggesting that a state of somatomotor hyperarousal may be associated with poorer sleep quality in this group. However, in the pain group, greater PSQI scores were associated with less dorsostriatal-sensorimotor rsFC, possibly due to a shift of striatal functions toward regulation sensorimotor aspects of the pain experience, and/or aberrant cortico-striatal loops in the presence of chronic pain. This preliminary investigation advances knowledge about the neurobiology underlying the associations between chronic pain and sleep in community-dwelling older adults that may contribute to the development of effective therapies to decrease disability in geriatric populations.
引用
下载
收藏
页数:12
相关论文
共 50 条
  • [21] The Relationship between Chronic Musculoskeletal Pain and Sarcopenia Risk in Community-Dwelling Older Adults: A Cross-Sectional Study
    Sahin, Ulku Kezban
    Senturk, Aysun Yagci
    ANNALS OF GERIATRIC MEDICINE AND RESEARCH, 2023, 27 (03): : 250 - 257
  • [22] Association between dysphagia risk and sleep quality in community-dwelling older adults: A cross-sectional study
    Hama, Yohko
    Yamada, Sachiko
    Nishimura, Rumi
    Yoshida, Mitsuyoshi
    Tsuga, Kazuhiro
    Morita, Emi
    Tamada, Yudai
    Kato, Yasufumi
    Kubo, Yoko
    Okada, Rieko
    Nagayoshi, Mako
    Tamura, Takashi
    Hishida, Asahi
    Wakai, Kenji
    Naito, Mariko
    HELIYON, 2024, 10 (11)
  • [23] Relationship between Walking Activity and Sleep Quality among Community-Dwelling Older Adults
    Cheng, Hui-Ping
    Chen, Ching-Huey
    Lin, Huey-Shyan
    Wang, Jing-Jy
    Yen, Miaofen
    JOURNAL OF COMMUNITY HEALTH NURSING, 2022, 39 (02) : 127 - 138
  • [24] The Relationship between Sleep Quality and Frailty in Community-Dwelling Older Adults: Depression as a Mediator
    Liu, X. Y.
    Wang, C. L.
    Qiao, X. X.
    Tian, X. Y.
    Jin, Y. R.
    Si, H. X.
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2018, 66 : S500 - S500
  • [25] Relationship Between Physical Activity and Chronic Musculoskeletal Pain Among Community-Dwelling Japanese Adults
    Kamada, Masamitsu
    Kitayuguchi, Jun
    Lee, I-Min
    Hamano, Tsuyoshi
    Imamura, Fumiaki
    Inoue, Shigeru
    Miyachi, Motohiko
    Shiwaku, Kuninori
    JOURNAL OF EPIDEMIOLOGY, 2014, 24 (06) : 474 - 483
  • [26] Association between Chronic Pain and Sarcopenia in Greek Community-Dwelling Older Adults: A Cross-Sectional Study
    Tsekoura, Maria
    Billis, Evdokia
    Matzaroglou, Charalampos
    Tsepis, Elias
    Gliatis, John
    HEALTHCARE, 2024, 12 (13)
  • [27] Association between functional limitations and depression among community-dwelling older adults in Malaysia
    Ahmad, Noor Ani
    Abd Razak, Mohamad Aznuddin
    Kassim, Mohd ShaifulAzlan
    Sahril, Norhafizah
    Ahmad, Fazila Haryati
    Harith, Abdul Aziz
    Mahmud, Nur Azna
    Aziz, Fazly Azry Abdul
    Hasim, Mohd Hazrin
    Ismail, Hasimah
    Sidik, Sherina Mohd
    GERIATRICS & GERONTOLOGY INTERNATIONAL, 2020, 20 : 21 - 25
  • [28] Different Modulatory Effects of Cognitive Training and Aerobic Exercise on Resting State Functional Connectivity of Entorhinal Cortex in Community-Dwelling Older Adults
    Gu, NanNan
    Li, Hechun
    Cao, Xinyi
    Li, Ting
    Jiang, Lijuan
    Zhang, Han
    Zhao, Binglei
    Luo, Cheng
    Li, Chunbo
    FRONTIERS IN AGING NEUROSCIENCE, 2021, 13
  • [29] Association between dietary diversity and chronic kidney disease in community-dwelling older adults
    Kiuchi, Yuto
    Tsutsumimoto, Kota
    Nishimoto, Kazuhei
    Misu, Yuka
    Ohata, Tomoka
    Makizako, Hyuma
    Shimada, Hiroyuki
    EUROPEAN GERIATRIC MEDICINE, 2024, 15 (02) : 545 - 552
  • [30] Association between the empirical dietary inflammatory index and musculoskeletal pain in community-dwelling older adults: a cross-sectional study
    Rezaei, Mahshid
    Tajary, Zahra
    Esmaeily, Zahra
    Eyvazkhani, Atefeh
    Daei, Shahrzad
    Dara, Marjan Mansouri
    Rezaei, Mohaddeseh
    Djazayeri, Abolghassem
    Motlagh, Ahmadreza Dorosty
    OSONG PUBLIC HEALTH AND RESEARCH PERSPECTIVES, 2023, 14 (01) : 51 - 58