Identification of rTid-1, the rat homologue of the drosophila tumor suppressor l(2)tid gene

被引：4
|
作者：
Fujita, M [1 ]
Nagai, Y [1 ]
Sawada, T [1 ]
Heese, K [1 ]
机构：
[1] Natl Cardiovasc Ctr, BF Res Inst, Osaka 5650873, Japan
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2004年 / 258卷 / 1-2期
关键词：
apoptosis; heat shock protein; neurodegeneration; mortalin;
D O I：
10.1023/B:MCBI.0000012854.84126.69
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Active cell death ('apoptosis' or 'programmed cell death') is essential in the development and homeostasis of multicellular organisms and abnormal inhibition of apoptosis is an indicator of cancer and autoimmune diseases, whereas excessive cell death is implicated in neurodegenerative disorders such as Alzheimer's disease ( AD). Here we demonstrate new isoforms of the rat homologue of the drosophila tumor suppressor l(2) tid gene (rTid-1). Moreover, we show that rTid-1 interacts isoform-specifically with the heat-shock-cognate-glucose-regulated protein hscGRP75 and neither induces nor inhibits directly neuronal apoptosis. This finding points to a pivotal role of Tid-1 in the control of cellular survival.
引用
收藏
页码：183 / 189
页数：7
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