Identification of rTid-1, the rat homologue of the drosophila tumor suppressor l(2)tid gene

被引：4

作者：

Fujita, M ^{[1
]}

Nagai, Y ^{[1
]}

Sawada, T ^{[1
]}

Heese, K ^{[1
]}

机构：

[1] Natl Cardiovasc Ctr, BF Res Inst, Osaka 5650873, Japan

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2004年 / 258卷 / 1-2期

关键词：

apoptosis; heat shock protein; neurodegeneration; mortalin;

D O I：

10.1023/B:MCBI.0000012854.84126.69

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Active cell death ('apoptosis' or 'programmed cell death') is essential in the development and homeostasis of multicellular organisms and abnormal inhibition of apoptosis is an indicator of cancer and autoimmune diseases, whereas excessive cell death is implicated in neurodegenerative disorders such as Alzheimer's disease ( AD). Here we demonstrate new isoforms of the rat homologue of the drosophila tumor suppressor l(2) tid gene (rTid-1). Moreover, we show that rTid-1 interacts isoform-specifically with the heat-shock-cognate-glucose-regulated protein hscGRP75 and neither induces nor inhibits directly neuronal apoptosis. This finding points to a pivotal role of Tid-1 in the control of cellular survival.

引用

页码：183 / 189

页数：7

共 50 条

[21] Gene within gene configuration and expression of the Drosophila melanogaster genes lethal(2) neighbour of tid [l(2)not] and lethal(2) relative of tid [l(2) rot]
KurzikDumke, U
Kaymer, M
Gundacker, D
Debes, A
Labitzke, K
GENE, 1997, 200 (1-2) : 45 - 58
[22] Understanding human cancer using Drosophila -: Tid47, a cytosolic product of the DnaJ-like tumor suppressor gene l(2)tid, is a novel molecular partner of patched related to skin cancer
Canamasas, I
Debes, A
Natali, PG
Kurzik-Dumke, U
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (33) : 30952 - 30960
[23] Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor 1(2)tid, is critical for early embryonic development and cell survival
Lo, JF
Hayashi, M
Woo-Kim, S
Tian, B
Huang, JF
Fearns, C
Takayama, S
Zapata, JM
Yang, Y
Lee, JD
MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (06) : 2226 - 2236
[24] Identification and characterisation of the Drosophila homologue of the yeast Uba2 gene
Donaghue, C
Bates, H
Cotterill, S
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2001, 1518 (1-2): : 210 - 214
[25] Erratum: Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg
Hiroshi Fukuhara
Mari Masvuda
Mika Yageta
Takeshi Fukami
Masami Kuramochi
Tomoko Maruyama
Tadaichi Kitamura
Yoshinori Murakami
Oncogene, 2004, 23 : 629 - 629
[26] Expression of the rat homologue of the Drosophila fat tumour suppressor gene (vol 80, pg 207, 1999)
Ponassi, M
Jacques, TS
Ciani, L
ffrench-Constant, C
MECHANISMS OF DEVELOPMENT, 1999, 88 (01) : 127 - 127
[27] Identification of Slit2 as a tumor suppressor gene
Kim, H.
Li, H.
Elmets, C.
Xu, X.
Xu, H.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 : 15 - 15
[28] TRANSCRIPTIONAL AND TRANSLATIONAL REGULATION OF THE EXPRESSION OF THE L(2)GL TUMOR SUPPRESSOR GENE OF DROSOPHILA-MELANOGASTER
STRAND, D
TOROK, I
KALMES, A
SCHMIDT, M
MERZ, R
MECHLER, BM
ADVANCES IN ENZYME REGULATION, 1991, 31 : 339 - +
[29] SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers
Dallol, A
Da Silva, NF
Viacava, P
Minna, JD
Bieche, I
Maher, ER
Latif, F
CANCER RESEARCH, 2002, 62 (20) : 5874 - 5880
[30] SLIT2, a human homologue of the Drosophila Slit2 gene has tumor suppressor activity and is frequently inactivated in lung and breast cancers
Dallol, A
Da Silva, NF
Viacava, P
Minna, JD
Tessier-Lavigne, M
Maher, ER
Latif, F
JOURNAL OF MEDICAL GENETICS, 2002, 39 : S15 - S15

← 1 2 3 4 5 →