Pd-catalyzed synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles

被引：19
|
作者：
Balalaie, Saeed [1 ]
Motaghedi, Hassan [1 ]
Bararjanian, Morteza [1 ]
Tahmassebi, Daryoush [2 ]
Bijanzadeh, Hamid Reza [3 ]
机构：
[1] KN Tossi Univ Technol, Peptide Chem Res Ctr, Tehran, Iran
[2] Indiana Univ Purdue Univ, Dept Chem, Ft Wayne, IN 46805 USA
[3] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
来源：
TETRAHEDRON | 2011年 / 67卷 / 47期
关键词：
3-(Diarylmethylene)-2-oxindoles; 3-(Atylmethylene)-2-oxindoles; Modified Heck reaction; Palladium catalyst; PROTEASOME INHIBITORS TMC-95A; GROWTH-FACTOR RECEPTOR; C-H FUNCTIONALIZATION; TYROSINE KINASE; STEREOSELECTIVE-SYNTHESIS; SELECTIVE SYNTHESIS; BOND FORMATION; RING-SYSTEM; HETEROCYCLES; DISCOVERY;
D O I：
10.1016/j.tet.2011.09.089
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the stereoselective synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles via carbopalladation is described. In this approach. an Ugi-4-component reaction (4-CR) adduct was used as the starting material. A one-pot sequence involving intermolecular carbopalladation C-H activation/C-C bond formation efficiently afforded the oxindole derivatives. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9134 / 9141
页数：8
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