Autoxidation/Aldol Tandem Reaction of 2-Oxindoles with Ketones: A Green Approach for the Synthesis of 3-Hydroxy-2-Oxindoles

被引：18
|
作者：
Zhang, Qing-Bao [1 ]
Jia, Wen-Liang [1 ]
Ban, Yong-Liang [1 ]
Zheng, Yong [1 ]
Liu, Qiang [1 ]
Wu, Li-Zhu [2 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100864, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 08期
关键词：
autoxidation; C-H activation; oxindoles; oxygen; tetrabutylammonium fluoride; MOLECULAR-OXYGEN; SELECTIVE AUTOXIDATION; TERMINAL ALKYNES; CATALYZED OXIDATION; SINGLET OXYGEN; BOND-CLEAVAGE; LEWIS-ACID; OXINDOLES; HYDROXYLATION; ESTERS;
D O I：
10.1002/chem.201504282
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the presence of tetrabutylammonium fluoride and molecular sieves (MS) 4 angstrom in DMF, an efficient autoxidation reaction of 2-oxindoles with ketones under air at room temperature has been developed. This approach may provide a green, practical, and metal-free protocol for a wide range of biologically important 3-hydroxy-3-(2-oxo-alkyl)-2-oxindoles.
引用
收藏
页码：2595 / 2598
页数：4
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