Pd-catalyzed synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles

被引：19

作者：

Balalaie, Saeed ^{[1
]}

Motaghedi, Hassan ^{[1
]}

Bararjanian, Morteza ^{[1
]}

Tahmassebi, Daryoush ^{[2
]}

Bijanzadeh, Hamid Reza ^{[3
]}

机构：

[1] KN Tossi Univ Technol, Peptide Chem Res Ctr, Tehran, Iran

[2] Indiana Univ Purdue Univ, Dept Chem, Ft Wayne, IN 46805 USA

[3] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON | 2011年 / 67卷 / 47期

关键词：

3-(Diarylmethylene)-2-oxindoles; 3-(Atylmethylene)-2-oxindoles; Modified Heck reaction; Palladium catalyst; PROTEASOME INHIBITORS TMC-95A; GROWTH-FACTOR RECEPTOR; C-H FUNCTIONALIZATION; TYROSINE KINASE; STEREOSELECTIVE-SYNTHESIS; SELECTIVE SYNTHESIS; BOND FORMATION; RING-SYSTEM; HETEROCYCLES; DISCOVERY;

D O I：

10.1016/j.tet.2011.09.089

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the stereoselective synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles via carbopalladation is described. In this approach. an Ugi-4-component reaction (4-CR) adduct was used as the starting material. A one-pot sequence involving intermolecular carbopalladation C-H activation/C-C bond formation efficiently afforded the oxindole derivatives. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：9134 / 9141

页数：8

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