A new method for the synthesis of peptide nucleic acids

被引：0

作者：

Wexselblatt, E. ^{[1
]}

Yavin, E. ^{[1
]}

Katzhendler, J. ^{[1
]}

Vaksman, O.

Reich, R.

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Dept Med Chem & Nat Prod, IL-91905 Jerusalem, Israel

来源：

CHEMISTRY OF NUCLEIC ACID COMPONENTS | 2008年 / 10卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel synthetic method for PNA oligomerization was developed. To this end, a new a-amino protecting group was introduced. This protecting group, namely NPS, may be removed under reductive mild acidic conditions, thus avoiding possible undesirable transacylation. Antisense PNA sequences prepared by this method were satisfactory tested in vitro showing silencing potency similar to that found for analogous siRNA.

引用

页码：471 / 472

页数：2

共 50 条

[31] Solid-phase synthesis of novel peptide nucleic acids
Lowe, G
Vilaivan, T
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1997, (04): : 555 - 560
[32] Peptide Nucleic Acids: Recent Developments in the Synthesis and Backbone Modifications
Singh, Gurpreet
Monga, Vikramdeep
BIOORGANIC CHEMISTRY, 2023, 141
[33] Synthesis, analysis, purification, and intracellular delivery of peptide nucleic acids
Braasch, DA
Corey, DR
METHODS, 2001, 23 (02) : 97 - 107
[34] A novel concept for the combinatorial synthesis of peptide nucleic acids.
Dömling, A
NUCLEOSIDES & NUCLEOTIDES, 1998, 17 (9-11): : 1667 - 1670
[35] Synthesis and properties of peptide nucleic acids containing a psoralen unit
Okamoto, A
Tanabe, K
Saito, I
ORGANIC LETTERS, 2001, 3 (06) : 925 - 927
[36] An efficient method of improving the cellular uptake of peptide nucleic acids
Basu, S
Wickstrom, E
FASEB JOURNAL, 1996, 10 (03): : 2574 - 2574
[37] Peptide nucleic acids (PNA): Synthesis, properties and potential applications
Hyrup, B
Nielsen, PE
BIOORGANIC & MEDICINAL CHEMISTRY, 1996, 4 (01) : 5 - 23
[38] THE STRUCTURE OF NUCLEIC ACIDS - A NEW METHOD OF DEGRADATION
LIPKIN, D
DIXON, JS
SCIENCE, 1952, 116 (3020) : 525 - 525
[39] Applications of peptide nucleic acids
Nielsen, PE
CURRENT OPINION IN BIOTECHNOLOGY, 1999, 10 (01) : 71 - 75
[40] Antisense peptide nucleic acids
Nielsen, PE
CURRENT OPINION IN MOLECULAR THERAPEUTICS, 2000, 2 (03) : 282 - 287

← 1 2 3 4 5 →