A new method for the synthesis of peptide nucleic acids

被引：0

作者：

Wexselblatt, E. ^{[1
]}

Yavin, E. ^{[1
]}

Katzhendler, J. ^{[1
]}

Vaksman, O.

Reich, R.

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Dept Med Chem & Nat Prod, IL-91905 Jerusalem, Israel

来源：

CHEMISTRY OF NUCLEIC ACID COMPONENTS | 2008年 / 10卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel synthetic method for PNA oligomerization was developed. To this end, a new a-amino protecting group was introduced. This protecting group, namely NPS, may be removed under reductive mild acidic conditions, thus avoiding possible undesirable transacylation. Antisense PNA sequences prepared by this method were satisfactory tested in vitro showing silencing potency similar to that found for analogous siRNA.

引用

页码：471 / 472

页数：2

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