Pure compound libraries; a new perspective for natural product based drug discovery

被引:104
|
作者
Bindseil, KU
Jakupovic, J
Wolf, D
Lavayre, J
Leboul, J
van der Pyl, D
机构
[1] AnalytiCon Discovery, D-14473 Potsdam, Germany
[2] Aventis Pharma, F-94403 Vitry Sur Seine, France
关键词
D O I
10.1016/S1359-6446(01)01856-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
What often distinguishes the leaders in drug discovery and development from the rest is the quality of their compound libraries and the ease of access that they have to the information within those libraries. The screening of natural products can provide greater structural diversity than standard synthetic chemistry and offers significant opportunities for finding novel low molecular weight lead compounds. However, which strategy is the best for natural-product-based drug discovery? Two well established but relatively time consuming approaches are the screening of crude extracts and pre-fractionated extracts. This case study describes a third, pure-compound-screening approach, and discusses its benefits and pitfalls.
引用
收藏
页码:840 / 847
页数:8
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