Recent developments in natural product-based drug discovery for tuberculosis

被引：27

作者：

Dong, Maryline ^{[1
]}

Pfeiffer, Bernhard ^{[1
]}

Altmann, Karl-Heinz ^{[1
]}

机构：

[1] ETH, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, Vladimir Prelog Weg 4,HCI H 405, CH-8093 Zurich, Switzerland

来源：

DRUG DISCOVERY TODAY | 2017年 / 22卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

MYCOBACTERIUM-TUBERCULOSIS; DIAZAQUINOMYCIN-A; TIACUMICIN B; LIPIARMYCIN; INHA; ANTIBIOTICS; PYRIDOMYCIN; TARGET; CAPRAZAMYCINS; ANALOGS;

D O I：

10.1016/j.drudis.2016.11.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Natural products (NPs) have been at the origin of several established drugs against tuberculosis (TB). Although the current clinical TB pipeline does not feature any candidates derived from new NP scaffolds, numerous novel NPs or NP analogs have been discovered in the recent past with promising activity against Mycobacterium tuberculosis (Mtb). This includes newly discovered structures as well as known NP classes that had not been previously recognized to be active against Mtb. These compounds could help to replenish the dry clinical TB pipeline and, thus, contribute to improvements in the treatment of a devastating disease.

引用

页码：585 / 591

页数：7

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