Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children

被引：0
|
作者：
Horstmann, Martin A. [1 ]
Hassenpflug, Wolf-Achim [1 ]
zur Stadt, Udo [1 ]
Escherich, Gabi [1 ]
Janka, Gritta [1 ]
Kabisch, Hartmut [1 ]
机构：
[1] Univ Med Ctr Hamburg Eppendorf, Clin Pediat Oncol & Hematol, Martinstr 52, D-20246 Hamburg, Germany
来源：
HAEMATOLOGICA | 2005年 / 90卷 / 12期
关键词：
pediatrics; acute lymphoblastic leukemia; salvage; amsacrine; etoposide; prednisolone; minimal residual disease;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In a retrospective analysis of 24 children with refractory or multiply relapsed acute lymphoblastic leukemia (ALL), a salvage regimen comprising amsacrine, etoposide, and high-dose methylprednisolone AEP achieved a significant treatment response in 11 of 19 evaluable patients (8 complete and 3 partial remissions). Five of 9 AEP-responsive patients who underwent subsequent stem cell transplantation are alive (median follow-up: 43 months; range 10 to 91). The load of minimal residual disease prior to transplantation appears to be predictive for outcome in this very poor-prognosis subgroup of ALL.
引用
收藏
页码：1701 / +
页数：3
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