Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children

被引：0

作者：

Horstmann, Martin A. ^{[1
]}

Hassenpflug, Wolf-Achim ^{[1
]}

zur Stadt, Udo ^{[1
]}

Escherich, Gabi ^{[1
]}

Janka, Gritta ^{[1
]}

Kabisch, Hartmut ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Clin Pediat Oncol & Hematol, Martinstr 52, D-20246 Hamburg, Germany

来源：

HAEMATOLOGICA | 2005年 / 90卷 / 12期

关键词：

pediatrics; acute lymphoblastic leukemia; salvage; amsacrine; etoposide; prednisolone; minimal residual disease;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a retrospective analysis of 24 children with refractory or multiply relapsed acute lymphoblastic leukemia (ALL), a salvage regimen comprising amsacrine, etoposide, and high-dose methylprednisolone AEP achieved a significant treatment response in 11 of 19 evaluable patients (8 complete and 3 partial remissions). Five of 9 AEP-responsive patients who underwent subsequent stem cell transplantation are alive (median follow-up: 43 months; range 10 to 91). The load of minimal residual disease prior to transplantation appears to be predictive for outcome in this very poor-prognosis subgroup of ALL.

引用

页码：1701 / +

页数：3

共 50 条

[21] A NEW REGIMEN OF AMSACRINE WITH HIGH-DOSE CYTARABINE IS SAFE AND EFFECTIVE THERAPY FOR ACUTE-LEUKEMIA
ARLIN, ZA
AHMED, T
MITTELMAN, A
FELDMAN, E
MEHTA, R
WEINSTEIN, P
RIEBER, E
SULLIVAN, P
BASKIND, P
[J]. CANCER INVESTIGATION, 1986, 4 (05) : 497 - 497
[22] A NEW REGIMEN OF AMSACRINE WITH HIGH-DOSE CYTARABINE IS SAFE AND EFFECTIVE THERAPY FOR ACUTE-LEUKEMIA
ARLIN, ZA
AHMED, T
MITTELMAN, A
FELDMAN, E
MEHTA, R
WEINSTEIN, P
RIEBER, E
SULLIVAN, P
BASKIND, P
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (03) : 371 - 375
[23] Salvage therapy with mitoxantrone, etoposide and cytarabine in relapsed or refractory acute lymphoblastic leukemia
Liedtke, Michaela
Dunn, Tamara
Dinner, Shira
Coutre, Steven E.
Berubea, Caroline
Gotlib, Jason
Patel, Samit
Medeiros, Bruno
[J]. LEUKEMIA RESEARCH, 2014, 38 (12) : 1441 - 1445
[24] A comparison of the effect of high-dose methylprednisolone with conventional-dose prednisolone in acute lymphoblastic leukemia patients with randomization
Yetgin, S
Gürgey, A
Tuncer, AM
Çetin, M
Özbek, N
Sayli, T
Güler, E
Kara, A
Olcay, L
Duru, F
Gümrük, F
Atahan, L
Tunçbilek, E
[J]. LEUKEMIA RESEARCH, 1998, 22 (06) : 485 - 493
[25] HIGH-DOSE CYCLOPHOSPHAMIDE THERAPY IN CHILDREN WITH ADVANCED ACUTE LEUKEMIA
FERNBACH, DJ
STARLING, KA
JONES, RR
OLIVOS, BJ
[J]. PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1971, 12 (NMAR): : 86 - &
[26] High-dose cytarabine, etoposide and cisplatin salvage chemotherapy for relapsed adult acute myeloid leukemia.
Lee, JS
Lee, KW
Lee, WS
Kim, J
Yoon, SS
Park, S
Kim, BK
[J]. BLOOD, 2003, 102 (11) : 230B - 230B
[27] High-dose therapy in acute leukemia
Carlo-Stella, C
Mangoni, L
Caramatti, C
Almici, C
Rizzoli, V
[J]. LEUKEMIA & LYMPHOMA, 1997, 26 : 61 - 67
[28] Hypertension, high-dose corticosteroids, and renal infiltration in children with acute lymphoblastic leukemia
Juliansen, Andry
Andriastuti, Murti
Pardede, Sudung O.
Sekartini, Rini
[J]. PAEDIATRICA INDONESIANA, 2014, 54 (06) : 372 - 376
[29] High-Dose Methotrexate-Related Toxicity in Children with Acute Lymphoblastic Leukemia
Gustafsson, Christina Egnell
Frederiksen, Grete Gotzsche
Thorwaldson, Josefine
Heyman, Mats
Harila-Saari, Arja
Ranta, Susanna
[J]. BLOOD, 2022, 140 : 6033 - 6034
[30] High-dose methotrexate for the treatment of acute lymphoblastic leukemia in children (a pharmacokinetic study)
Slany, J
Grundmann, M
Brozmanova, H
Blazek, B
Sterba, J
[J]. DRUG RESISTANCE IN LEUKEMIA AND LYMPHOMA II, 1997, 3 : 183 - 188

← 1 2 3 4 5 →