The interaction of the anticancer drug hypocrellin B (HB) or the mono-cysteine substituted hypocrellin B (MCHB) and calf thymus deoxyribonucleic acid (CT-DNA) has been investigated using spectral methods. The results of UV-visible spectra show that the 1113 and MCHB could intercalate into the base-stacking domain of the CT-DNA double helix. The studies of fluorescence spectra and circular dichroism(CD) spectra also support the interacalation mechanism.
机构:
Institute of Photographic Chemistry, Academia Sinica, Beijing, 100101, ChinaInstitute of Photographic Chemistry, Academia Sinica, Beijing, 100101, China
Weng, Min
Zhang, Man-Hua
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机构:
Institute of Photographic Chemistry, Academia Sinica, Beijing, 100101, ChinaInstitute of Photographic Chemistry, Academia Sinica, Beijing, 100101, China
Zhang, Man-Hua
Shen, Tao
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Institute of Photographic Chemistry, Academia Sinica, Beijing, 100101, ChinaInstitute of Photographic Chemistry, Academia Sinica, Beijing, 100101, China