Interaction of hypocrellin B or mono-cysteine substituted hypocrellin B with CT-DNA by spectral methods

被引：0
|
作者：
Zhou, JH [1 ]
Xia, SQ [1 ]
Wang, XS [1 ]
Zhang, BW [1 ]
Cao, Y [1 ]
机构：
[1] Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100101, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2003年 / 14卷 / 10期
关键词：
hypocrellin B; mono-cysteine substituted hypocrellin B; CT-DNA; interacalation mechanism;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The interaction of the anticancer drug hypocrellin B (HB) or the mono-cysteine substituted hypocrellin B (MCHB) and calf thymus deoxyribonucleic acid (CT-DNA) has been investigated using spectral methods. The results of UV-visible spectra show that the 1113 and MCHB could intercalate into the base-stacking domain of the CT-DNA double helix. The studies of fluorescence spectra and circular dichroism(CD) spectra also support the interacalation mechanism.
引用
收藏
页码：1054 / 1057
页数：4
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