The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia

被引：44
|
作者：
La Nasa, Giorgio
Littera, Roberto
Locatelli, Franco
Lai, Sara
Alba, Francesco
Caocci, Giovanni
Lisini, Daniela
Nesci, Sonia
Vacca, Adriana
Piras, Eugenia
Bernardo, Maria Ester
Cesare-Merlone, Alessandra Di
Orru, Sandro
Carcassi, Carlo
机构：
[1] Univ Cagliari, Cattedra Genet Med, Osped R Binaghi, Dipartimento Sci Med Internist, I-09126 Cagliari, Italy
[2] Univ Cagliari, Dipartimento Sci Mediche Internistiche, Osped R Binaghi, Ctr Trapianti Midollo Osseo,Cattedra Ematol, Cagliari, Italy
[3] Osped R Binaghi, Ctr Res Trapianti, Cagliari, Italy
[4] Univ Pavia, Policlin San Matteo, Fonaz IRCCS, I-27100 Pavia, Italy
[5] Osped S Salvatore, Ctr Trapianti Midollo Osseo Muraglia, Unita Operat Ematol, Pesaro, Italy
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 139卷 / 02期
关键词：
human leucocyte antigen-G; 14-basepair polymorphism; acute graft-versus-host disease; thalassaemia; bone marrow transplantation;
D O I：
10.1111/j.1365-2141.2007.06779.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.
引用
收藏
页码：284 / 288
页数：5
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