The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia

被引：44
|
作者：
La Nasa, Giorgio
Littera, Roberto
Locatelli, Franco
Lai, Sara
Alba, Francesco
Caocci, Giovanni
Lisini, Daniela
Nesci, Sonia
Vacca, Adriana
Piras, Eugenia
Bernardo, Maria Ester
Cesare-Merlone, Alessandra Di
Orru, Sandro
Carcassi, Carlo
机构：
[1] Univ Cagliari, Cattedra Genet Med, Osped R Binaghi, Dipartimento Sci Med Internist, I-09126 Cagliari, Italy
[2] Univ Cagliari, Dipartimento Sci Mediche Internistiche, Osped R Binaghi, Ctr Trapianti Midollo Osseo,Cattedra Ematol, Cagliari, Italy
[3] Osped R Binaghi, Ctr Res Trapianti, Cagliari, Italy
[4] Univ Pavia, Policlin San Matteo, Fonaz IRCCS, I-27100 Pavia, Italy
[5] Osped S Salvatore, Ctr Trapianti Midollo Osseo Muraglia, Unita Operat Ematol, Pesaro, Italy
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 139卷 / 02期
关键词：
human leucocyte antigen-G; 14-basepair polymorphism; acute graft-versus-host disease; thalassaemia; bone marrow transplantation;
D O I：
10.1111/j.1365-2141.2007.06779.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.
引用
收藏
页码：284 / 288
页数：5
相关论文
共 50 条
  • [21] GRAFT-VERSUS-HOST DISEASE IN EXPERIMENTAL ALLOGENEIC BONE-MARROW TRANSPLANTATION
    KORNGOLD, R
    SPRENT, J
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1991, 197 (01): : 12 - 18
  • [22] CYTOKINES IN THE PATHOGENESIS OF ACUTE HUMAN GRAFT-VERSUS-HOST DISEASE (GVHD) FOLLOWING UNRELATED DONOR BONE-MARROW TRANSPLANTATION (URBMT)
    PARKMAN, R
    LAWRENCE, K
    BARRANTOS, B
    WEINBERG, K
    JOURNAL OF IMMUNOLOGY, 1993, 150 (08): : A320 - A320
  • [23] Bone marrow infarction due to acute graft-versus-host disease in an acute lymphoblastic leukemia patient after unrelated bone marrow transplantation
    A Mori
    S Hashino
    M Imamura
    K Kahata
    H Kawakami
    M Shibata
    S Kobayashi
    J Tanaka
    M Asaka
    Bone Marrow Transplantation, 1998, 21 : 615 - 617
  • [24] Immunomodulating functions of human leukocyte antigen-G and its role in graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    Bu, Xiaoyin
    Zhong, Jinman
    Li, Weiru
    Cai, Shengchun
    Gao, Ya
    Ping, Baohong
    ANNALS OF HEMATOLOGY, 2021, 100 (06) : 1391 - 1400
  • [25] Immunomodulating functions of human leukocyte antigen-G and its role in graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    Xiaoyin Bu
    Jinman Zhong
    Weiru Li
    Shengchun Cai
    Ya Gao
    Baohong Ping
    Annals of Hematology, 2021, 100 : 1391 - 1400
  • [26] Avascular necrosis in the femoral head secondary to bone marrow infarction in a patient with graft-versus-host disease after unrelated bone marrow transplantation
    Mori, A
    Hashino, S
    Kobayashi, S
    Tanaka, J
    Yamamoto, Y
    Asaka, M
    Imamura, M
    ANNALS OF HEMATOLOGY, 2001, 80 (04) : 238 - 242
  • [27] Bone marrow infarction due to acute graft-versus-host disease in an acute lymphoblastic leukemia patient after unrelated bone marrow transplantation
    Mori, A
    Hashino, S
    Imamura, M
    Kahata, K
    Kawakami, H
    Shibata, M
    Kobayashi, S
    Tanaka, J
    Asaka, M
    BONE MARROW TRANSPLANTATION, 1998, 21 (06) : 615 - 617
  • [28] Avascular necrosis in the femoral head secondary to bone marrow infarction in a patient with graft-versus-host disease after unrelated bone marrow transplantation
    Akio Mori
    Satoshi Hashino
    Sumiko Kobayashi
    Junji Tanaka
    Yasushi Yamamoto
    Masahiro Asaka
    Masahiro Imamura
    Annals of Hematology, 2001, 80 : 238 - 242
  • [29] Lack of correlation of MLC reactivity with acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation
    Segall, M
    Noreen, H
    Edwins, L
    Haake, R
    Shu, XO
    Kersey, J
    HUMAN IMMUNOLOGY, 1996, 49 (01) : 49 - 55
  • [30] Combination of tacrolimus, methotrexate, and methylprednisolone prevents acute but not chronic graft-versus-host disease in unrelated bone marrow transplantation
    Ogawa, H
    Soma, T
    Hosen, N
    Tatekawa, T
    Tsuboi, A
    Oji, Y
    Tamaki, H
    Kawakami, M
    Ikegame, K
    Murakami, M
    Fujioka, T
    Kim, EH
    Oka, Y
    Sugiyama, H
    TRANSPLANTATION, 2002, 74 (02) : 236 - 243
12345