Function of DnaA protein, the initiator for chromosomal DNA replication in E-coli

被引：0
|
作者：
Mizushima, T [1 ]
机构：
[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1998年 / 118卷 / 07期
关键词：
DNA replication; DnaA protein; ATPase; gene expression; phospholipid; inhibitor;
D O I：
10.1248/yakushi1947.118.7_257
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
DnaA protein is an initiator for chromosomal DNA replication in E. coli. We have examined the function of the protein to answer the foollowing four questions; (1) How DnaA protein is inactivated after DNA replication for the suppression of re-initiation ? (2) How DnaA protein is activated for the initiation of DNA replication ? (3) Does DnaA protein have functions other than that for DNA replication? (4) Is DnaA protein is a good target for new antibiotics? In this review, I summarize our recent studies for these questions.
引用
收藏
页码：257 / 271
页数：15
相关论文
共 50 条
  • [41] THE DNAA INITIATOR PROTEIN BINDS SEPARATE DOMAINS IN THE REPLICATION ORIGIN OF ESCHERICHIA-COLI
    YUNG, BYM
    KORNBERG, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1989, 264 (11) : 6146 - 6150
  • [42] The bacterial replication initiator DnaA.: DnaA and oriC, the bacterial mode to initiate DNA replication
    Messer, W
    FEMS MICROBIOLOGY REVIEWS, 2002, 26 (04) : 355 - 374
  • [43] INTERACTION OF THE INITIATOR PROTEIN DNAA OF ESCHERICHIA-COLI WITH ITS DNA TARGET
    SCHAPER, S
    MESSER, W
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (29) : 17622 - 17626
  • [44] INITIATION OF CHROMOSOMAL DNA-REPLICATION WHICH IS STIMULATED WITHOUT OVERSUPPLY OF DNAA PROTEIN IN ESCHERICHIA-COLI
    KATAYAMA, T
    NAGATA, T
    MOLECULAR & GENERAL GENETICS, 1991, 226 (03): : 491 - 502
  • [45] Soj/ParA stalls DNA replication by inhibiting helix formation of the initiator protein DnaA
    Scholefield, Graham
    Errington, Jeff
    Murray, Heath
    EMBO JOURNAL, 2012, 31 (06): : 1542 - 1555
  • [46] THE COMPLEX OF ORIC DNA WITH THE DNAA INITIATOR PROTEIN
    MESSER, W
    EGAN, B
    GILLE, H
    HOLZ, A
    SCHAEFER, C
    WOELKER, B
    RESEARCH IN MICROBIOLOGY, 1991, 142 (2-3) : 119 - 125
  • [47] Identification of a putative chromosomal replication origin from Helicobacter pylori and its interaction with the initiator protein DnaA
    Zawilak, A
    Cebrat, S
    Mackiewicz, P
    Król-Hulewicz, A
    Jakimowicz, D
    Messer, W
    Gosciniak, G
    Zakrzewska-Czerwinska, J
    NUCLEIC ACIDS RESEARCH, 2001, 29 (11) : 2251 - 2259
  • [48] FLUID MEMBRANES WITH ACIDIC DOMAINS ACTIVATE DNAA, THE INITIATOR PROTEIN OF REPLICATION IN ESCHERICHIA-COLI
    CASTUMA, CE
    CROOKE, E
    KORNBERG, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1993, 268 (33) : 24665 - 24668
  • [49] THE INITIATOR PROTEIN DNAA - EVOLUTION, PROPERTIES AND FUNCTION
    SKARSTAD, K
    BOYE, E
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1994, 1217 (02): : 111 - 130
  • [50] Regulation of chromosomal replication by DnaA protein availability in Escherichia coli:: effects of the datA region
    Morigen
    Boye, E
    Skarstad, K
    Lobner-Olesen, A
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2001, 1521 (1-3): : 73 - 80
12345