Function of DnaA protein, the initiator for chromosomal DNA replication in E-coli

被引：0

作者：

Mizushima, T ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1998年 / 118卷 / 07期

关键词：

DNA replication; DnaA protein; ATPase; gene expression; phospholipid; inhibitor;

D O I：

10.1248/yakushi1947.118.7_257

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

DnaA protein is an initiator for chromosomal DNA replication in E. coli. We have examined the function of the protein to answer the foollowing four questions; (1) How DnaA protein is inactivated after DNA replication for the suppression of re-initiation ? (2) How DnaA protein is activated for the initiation of DNA replication ? (3) Does DnaA protein have functions other than that for DNA replication? (4) Is DnaA protein is a good target for new antibiotics? In this review, I summarize our recent studies for these questions.

引用

页码：257 / 271

页数：15

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