Function of DnaA protein, the initiator for chromosomal DNA replication in E-coli

被引：0
|
作者：
Mizushima, T [1 ]
机构：
[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1998年 / 118卷 / 07期
关键词：
DNA replication; DnaA protein; ATPase; gene expression; phospholipid; inhibitor;
D O I：
10.1248/yakushi1947.118.7_257
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
DnaA protein is an initiator for chromosomal DNA replication in E. coli. We have examined the function of the protein to answer the foollowing four questions; (1) How DnaA protein is inactivated after DNA replication for the suppression of re-initiation ? (2) How DnaA protein is activated for the initiation of DNA replication ? (3) Does DnaA protein have functions other than that for DNA replication? (4) Is DnaA protein is a good target for new antibiotics? In this review, I summarize our recent studies for these questions.
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页码：257 / 271
页数：15
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