Cross Talk between Wnt/β-Catenin and CIP2A/Plk1 Signaling in Prostate Cancer: Promising Therapeutic Implications

被引：15
|
作者：
Cristobal, Ion [1 ]
Rojo, Federico [2 ]
Madoz-Gurpide, Juan [2 ]
Garcia-Foncillas, Jesus [1 ]
机构：
[1] UAM, Univ Hosp Fdn Jimenez Diaz, Oncohlth Inst, Translat Oncol Div,IIS Fdn Jimenez Diaz, Madrid, Spain
[2] UAM, IIS Fdn Jimenez Diaz, Dept Pathol, Madrid, Spain
来源：
MOLECULAR AND CELLULAR BIOLOGY | 2016年 / 36卷 / 12期
关键词：
POLO-LIKE-KINASE; SMALL INTERFERING RNA; CELL LUNG-CANCER; BIPOLAR SPINDLE FORMATION; BETA-CATENIN; ANDROGEN RECEPTOR; BREAST-CANCER; PLK1; POLO-LIKE-KINASE-1; PROGNOSTIC-SIGNIFICANCE;
D O I：
10.1128/MCB.00130-16
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aberrant activation of the Wnt/beta-catenin pathway and polo-like kinase 1 (Plk1) overexpression represent two common events in prostate cancer with relevant functional implications. This minireview analyzes their potential therapeutic significance in prostate cancer based on their role as androgen receptor (AR) signaling regulators and the pivotal role of the tumor suppressor protein phosphatase 2A (PP2A) modulating these pathways.
引用
收藏
页码：1734 / 1739
页数：6
相关论文
共 50 条
  • [31] Psoralen mediates BMSCs osteogenic differentiation via cross-talk between Wnt/β-catenin and BMP/smad signaling pathways
    Li, Wenxiong
    Chen, Feifei
    Chen, Menghan
    Zhong, Yuan
    Yang, Feng
    PHYSIOLOGY, 2024, 39
  • [32] Numb/Notch/PLK1 signaling pathway mediated hyperglycemic memory in pancreatic cancer cell radioresistance and the therapeutic effects of metformin
    Zhu, Dandan
    Xia, Jie
    Liu, Chao
    Fang, Chi
    CELLULAR SIGNALLING, 2022, 93
  • [33] LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance
    Huang, Yuhan
    Zhang, Rui
    Lyu, Hao
    Xiao, Shuai
    Guo, Dong
    Chen, Xing-Zhen
    Zhou, Cefan
    Tang, Jingfeng
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2024, 20 (07): : 2698 - 2726
  • [34] Identification of a cross-talk between EGFR and Wnt/beta-catenin signaling pathways in HepG2 liver cancer cells (vol 79, 109885, 2021)
    Singh, Gurjinder
    Hossain, Md Mehedi
    Bhat, Aadil Qadir
    Ayaz, Mir Owais
    Bano, Nasima
    Eachkoti, Rafiqa
    Dar, Mohd Jamal
    CELLULAR SIGNALLING, 2023, 108
  • [35] Polyphyllin I inhibits invasion and epithelial-mesenchymal transition via CIP2A/PP2A/ERK signaling in prostate cancer
    Liu, Xuewen
    Sun, Zhiting
    Deng, Jikun
    Liu, Jun
    Ma, Kaihuai
    Si, Yuan
    Zhang, Te
    Feng, Tingting
    Liu, Ying
    Tan, Yan
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 53 (03) : 1279 - 1288
  • [36] Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells
    H Y Choi
    J E Lim
    J H Hong
    Prostate Cancer and Prostatic Diseases, 2010, 13 : 343 - 349
  • [37] Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells
    Choi, H. Y.
    Lim, J. E.
    Hong, J. H.
    PROSTATE CANCER AND PROSTATIC DISEASES, 2010, 13 (04) : 343 - 349
  • [38] Feedback between E2F1 and CIP2A regulated by human papillomavirus E7 in cervical cancer: implications for prognosis
    Wang, Xiao
    Gao, Peng
    Wang, Meng
    Liu, Jing
    Lin, Jiaxiang
    Zhang, Shule
    Zhao, Yiwei
    Zhang, Jingwen
    Pan, Wei
    Sun, Zeyu
    Sun, Feifei
    Zhao, Weiming
    Guo, Chenghao
    Wang, Qingwei
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2017, 9 (05): : 2327 - 2339
  • [39] Crosstalk between lncRNAs and Wnt/β-catenin signaling pathways in lung cancers: From cancer progression to therapeutic response
    Wu, Ting
    Dong, YiRan
    Yang, XinZhi
    Mo, Liang
    You, Yong
    NON-CODING RNA RESEARCH, 2024, 9 (03): : 667 - 677
  • [40] CIP2A mediates prostate cancer progression via the c-MYC signaling pathway (vol 36, pg 3583, 2015)
    Guo, Zexiong
    Liu, Dehao
    Su, Zexuan
    TUMOR BIOLOGY, 2015, 36 (08) : 6587 - 6587
12345