Cross Talk between Wnt/β-Catenin and CIP2A/Plk1 Signaling in Prostate Cancer: Promising Therapeutic Implications

被引：15

作者：

Cristobal, Ion ^{[1
]}

Rojo, Federico ^{[2
]}

Madoz-Gurpide, Juan ^{[2
]}

Garcia-Foncillas, Jesus ^{[1
]}

机构：

[1] UAM, Univ Hosp Fdn Jimenez Diaz, Oncohlth Inst, Translat Oncol Div,IIS Fdn Jimenez Diaz, Madrid, Spain

[2] UAM, IIS Fdn Jimenez Diaz, Dept Pathol, Madrid, Spain

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2016年 / 36卷 / 12期

关键词：

POLO-LIKE-KINASE; SMALL INTERFERING RNA; CELL LUNG-CANCER; BIPOLAR SPINDLE FORMATION; BETA-CATENIN; ANDROGEN RECEPTOR; BREAST-CANCER; PLK1; POLO-LIKE-KINASE-1; PROGNOSTIC-SIGNIFICANCE;

D O I：

10.1128/MCB.00130-16

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aberrant activation of the Wnt/beta-catenin pathway and polo-like kinase 1 (Plk1) overexpression represent two common events in prostate cancer with relevant functional implications. This minireview analyzes their potential therapeutic significance in prostate cancer based on their role as androgen receptor (AR) signaling regulators and the pivotal role of the tumor suppressor protein phosphatase 2A (PP2A) modulating these pathways.

引用

页码：1734 / 1739

页数：6

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