Synthesis of 2′-O-substituted ribonucleosides

被引：9

作者：

Serebryany, V ^{[1
]}

Beigelman, L ^{[1
]}

机构：

[1] Ribozyme Pharmaceut Inc, Boulder, CO 80301 USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

D O I：

10.1081/NCN-120022724

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient synthesis of 2'-O-substituted ribonucleosides, including 2'-O-TBDMS and 2'-O-TOM protected as well as 2'-O-Me and 2'-O-allyl derivatives is presented. Di-t-butylsilylene group was employed for simultaneous protection of 3'- and 5'-hydroxyl functions of nucleoside on the first step. Subsequent silylation or alkylation of free 2'-OH followed by introduction of suitable protection on the base moiety and removal of cyclic silyl protection gave target compounds in a high yield.

引用

页码：1007 / 1009

页数：3

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