Synthesis of 2′-O-substituted ribonucleosides

被引：9
|
作者：
Serebryany, V [1 ]
Beigelman, L [1 ]
机构：
[1] Ribozyme Pharmaceut Inc, Boulder, CO 80301 USA
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期
关键词：
D O I：
10.1081/NCN-120022724
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An efficient synthesis of 2'-O-substituted ribonucleosides, including 2'-O-TBDMS and 2'-O-TOM protected as well as 2'-O-Me and 2'-O-allyl derivatives is presented. Di-t-butylsilylene group was employed for simultaneous protection of 3'- and 5'-hydroxyl functions of nucleoside on the first step. Subsequent silylation or alkylation of free 2'-OH followed by introduction of suitable protection on the base moiety and removal of cyclic silyl protection gave target compounds in a high yield.
引用
收藏
页码：1007 / 1009
页数：3
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