Platelet-rich fibrin: An effective chronic wound healing accelerator

Background: Platelets are cells that play a central role in wound healing, and they are the main source of the growth factor complex that plays the main role in natural wound healing. It is aimed to present the beneficial effects of topical application of PRF on chronic ulcers that do not respond to standard wound care in cases of chronic ulcers that require a long treatment process and high costs. Materials and Methods: The study included 16 patients between the dates of January 2017 and September 2019. The study was approved by the local ethics board and planned retrospectively. Results: The mean number of PRF applications in the patients was 4.37 (range: 1-8), while the wounds of 10 patients were completely closed up to the mean number of applications, and at least 50% of the wounds of 4 patients were closed up to the mean number of applications. Discussion: Choukroun's platelet-rich fibrin may be considered as a 2nd-generation platelet concentration. Its preparation protocol is reported to be highly simple and low-cost. Conclusion: PRF is a safe, practical, easy to use adjuvant treatment method which has a potential for closing chronic wounds.