Impact of Platelet-Rich Plasma on Healing of Wound in Vocal Folds

Patients who presenting with hoarseness mostly show benign vocal folds (VFs) changes which required a combination of conservative and interventional treatment. Scarring during healing of vocal folds can lead to lifelong impairment of the vocal performance and decrease the quality of life. The aim of this study was to compare between the outcomes in healing of VFs wound with Platelet-rich plasma (PRP) and without PRP injection as regard restoration of vocal fold and voice. A total of 40 patients who presented with VFs benign tumor and admitted to surgical removal of tumor. Patients divided into two groups in equal numbers: groups (A) who had operated with sub epithelial injection of PRP, and group (B): who had operated without sub epithelial injection of PRP. All patients were subjected to the following: preoperative and surgical management, and postoperative follow up were evaluated. In our study, there was statistically significant difference between the two studied groups regarding healing (100% in group A and 60% in group B). There was a significant improvement all acoustic parameters and dysphonia in group A compared with group B who not injected with PRP. Injection of PRP for injured vocal folds during surgical benign tumor removal lead to improved wound healing and a fewer scar formation. Also, PRP was act as growth factor causing increased vocal fold regeneration.