Copper-catalyzed aerobic cascade reaction for the conversion of 3,4-dihydropyrimidine-2(1H)-thiones to arylthiopyrimidines

被引：12
|
作者：
Lee, Ok Suk [1 ]
Lee, HyunKyung [1 ]
Kim, Hyejee [1 ]
Shin, Hyunik [2 ]
Sohn, Jeong-Hun [1 ]
机构：
[1] Chungnam Natl Univ, Coll Nat Sci, Dept Chem, Taejon 305764, South Korea
[2] Yonsung Fine Chem R&D Ctr, Suwon 443380, South Korea
来源：
TETRAHEDRON | 2015年 / 71卷 / 19期
关键词：
Copper catalysis; Aerobic cascade reaction; C-S coupling; Oxidative dehydrogenation; Pyrimidine; COUPLING REACTIONS; OXIDATIVE DEHYDROGENATION; C-S; DEEP DESULFURIZATION; ARYL HALIDES; SULFUR; DIHYDROPYRIMIDINONES; NUCLEOPHILES; ARYLATION; ACCESS;
D O I：
10.1016/j.tet.2015.03.031
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Described is a copper-catalyzed cascade reaction method for the conversion of 3,4-dihydropyrimidine-2(1H)-thiones to arylthiopyrimidines, likely proceeded via C-S cross-coupling and oxidative dehydrogenation under aerobic conditions. The reaction method proceeded efficiently with a wide range of the dihydropyrimidinethione substrates and aryl iodides as coupling partners. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2936 / 2944
页数：9
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