Addition of Organolithium and Grignard Reagents to Pyrimidine-2(1H)-thione: Easy Access to 4-Substituted 3,4-Dihydropyrimidine-2(1H)-thiones

被引：5

作者：

Sosnicki, Jacek G. ^{[1
]}

机构：

[1] Tech Univ Szczecin, Inst Chem & Environm Protect, PL-71065 Szczecin, Poland

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2009年 / 184卷 / 08期

关键词：

3,4-Dihydropyrimidine-2(1H)-thiones; Grignard reagents; nucleophilic addition; organolithium reagents; pyrimidine-2(1H)-thione; ONE-POT SYNTHESIS; ANALGESIC ACTIVITIES; BIGINELLI REACTION; DERIVATIVES; PYRIMIDINE; MONASTROL; ANALOGS;

D O I：

10.1080/10426500903110066

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Organolithium andGrignard reagents are added to pyrimidine-2(1H)-thione, yielding 4-substituted 3,4-dihydropyrimidine-2-(1H)-thiones. Since the synthetic procedure can be performed on a multigram scale, and since pyrimidine-2(1H)-thione as well as the majority of organometallic reagents are readily available, the process described provides an easy access and complementary to other methods to 4-substituted 3,4-dihydropyrimidine-2-(1H)-thiones.

引用

页码：1946 / 1957

页数：12

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