A Pd-Catalyzed Synthesis of Functionalized Piperidines

被引：30

作者：

Allen, Benjamin D. W. ^{[1
]}

Connolly, Matthew J. ^{[1
]}

Harrity, Joseph P. A. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 37期

基金：

英国工程与自然科学研究理事会;

关键词：

annulation; enantioselectivity; Pd catalysis; piperidine; NATURAL-PRODUCT SYNTHESIS; 3+3 ANNELATION; CYCLOADDITION; TRIMETHYLENEMETHANE; HETEROCYCLES; ANNULATIONS; ALLYLATION; STRATEGY; IMINES; ROUTE;

D O I：

10.1002/chem.201602586

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A readily available cyclic carbamate 1 functions as a general precursor to a range of functionalized piperidine products via a new Pd-catalyzed annulation strategy. An asymmetric catalytic variant provides a rapid and efficient means to access these heterocycles with high to excellent levels of enantiocontrol. Finally, these richly functionalized compounds are amenable to further chemoselective elaboration.

引用

页码：12999 / 13003

页数：5

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