A Pd-Catalyzed Synthesis of Functionalized Piperidines

被引：30
|
作者：
Allen, Benjamin D. W. [1 ]
Connolly, Matthew J. [1 ]
Harrity, Joseph P. A. [1 ]
机构：
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 37期
基金：
英国工程与自然科学研究理事会;
关键词：
annulation; enantioselectivity; Pd catalysis; piperidine; NATURAL-PRODUCT SYNTHESIS; 3+3 ANNELATION; CYCLOADDITION; TRIMETHYLENEMETHANE; HETEROCYCLES; ANNULATIONS; ALLYLATION; STRATEGY; IMINES; ROUTE;
D O I：
10.1002/chem.201602586
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A readily available cyclic carbamate 1 functions as a general precursor to a range of functionalized piperidine products via a new Pd-catalyzed annulation strategy. An asymmetric catalytic variant provides a rapid and efficient means to access these heterocycles with high to excellent levels of enantiocontrol. Finally, these richly functionalized compounds are amenable to further chemoselective elaboration.
引用
收藏
页码：12999 / 13003
页数：5
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