Transition metal-free annulative vinylene transfer via the 1,3-dipolar reaction of N-ylides: access to benzo-fused indolizines

被引：19
|
作者：
Zhao, Limin
Li, Wen
Liu, Jiali
Ni, Linying
Liu, Zhihao
Shen, Hao
Cao, Hua
Liu, Xiang [1 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 48期
关键词：
CARBONATE; CYCLIZATION; STRATEGY; C1;
D O I：
10.1039/d2ob01846b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient metal-free annulative vinylene transfer protocol for the synthesis of benzo-fused indolizines via 1,3-dipolar cycloadditions of N-ylides with vinylene carbonate has been developed. Vinylene carbonate serves as an acetylene surrogate without any external oxidant involved. This transformation leads to the direct construction of versatile benzo-fused indolizine derivatives in moderate to good yields.
引用
收藏
页码：9604 / 9608
页数：5
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