Pressure-inactivated yellow fever 17DD virus:: Implications for vaccine development

被引：43

作者：

Gaspar, Luciane P. ^{[1
]}

Mendes, Ygara S. ^{[2
,3
]}

Yamamura, Anna M. Y. ^{[1
]}

Almeida, Luiz F. C. ^{[1
]}

Caride, Elena ^{[1
]}

Goncalves, Rafael B. ^{[2
,3
]}

Silva, Jerson L. ^{[2
,3
]}

Oliveira, Andrea C. ^{[2
,3
]}

Galler, Ricardo ^{[1
]}

Freire, Marcos S. ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz, Inst Tecnol Imunobiol, Programa Vacinas Virais, BR-21045900 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Inst Bioquim Med, Programa Biol Estrutural, BR-21941590 Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, Ctr Nacl Ressonancia Magnet Nucl Macromol Jiri Jo, Programa Biol Estrutural, BR-21941590 Rio De Janeiro, Brazil

来源：

JOURNAL OF VIROLOGICAL METHODS | 2008年 / 150卷 / 1-2期

关键词：

Yellow Fever 17DD virus; high pressure; virus inactivation;

D O I：

10.1016/j.jviromet.2008.03.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The successful Yellow Fever (YF) vaccine consists of the live attenuated 17D-204 or 17DD Viruses. Despite its excellent record of efficacy and safety, serious adverse events have been recorded and influenced extensive vaccination in endemic areas. Therefore, alternative strategies should be considered, which may include inactivated whole virus. High hydrostatic pressure has been described as a method for viral inactivation and vaccine development. The present study evaluated whether high hydrostatic pressure would inactivate the YF 17DD virus. YF 17DD virus was grown in Vero cells in roller bottle cultures and subjected to 310 MPa for 3 h at 4 degrees C. This treatment abolished YF infectivity and eliminated the ability of the virus to cause disease in mice. Pressure-inactivated virus elicited low level of neutralizing antibody titers although exhibited complete protection against an otherwise lethal challenge with 17DD virus in the murine model. The data warrant further development of pressure-inactivated vaccine against YF. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：57 / 62

页数：6

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