COMPARISON OF THE NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES OF THE STRUCTURAL PROTEIN GENES OF THE YELLOW-FEVER 17DD VACCINE STRAIN FROM SENEGAL WITH THOSE OF OTHER YELLOW-FEVER VACCINE VIRUSES

被引：17
|
作者：
JENNINGS, AD [1 ]
WHITBY, JE [1 ]
MINOR, PD [1 ]
BARRETT, ADT [1 ]
机构：
[1] NATL INST BIOL STAND & CONTROLS,DIV VIROL,POTTERS BAR EN6 3GQ,ENGLAND
来源：
VACCINE | 1993年 / 11卷 / 06期
关键词：
YELLOW FEVER; STRUCTURAL PROTEINS; FLAVIVIRUS;
D O I：
10.1016/0264-410X(93)90317-Q
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The nucleic acid and deduced amino acid sequences of the structural proteins of the 17DD vaccine strain of yellow fever (YF) virus originating from Senegal are compared with those published for other vaccine strains of YF virus. Even though the 17D-204 and 17DD substrains of 17D diverged at passage 195 of 17D, they show a very high degree of nucleotide (99.5%) and amino acid (99.5%) homology over this region. The sequences are discussed with respect to monoclonal antibodies that can distinguish between 17DD and 17D-204 substrains of YF vaccines.
引用
收藏
页码：679 / 681
页数：3
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