YELLOW-FEVER 17DD VACCINE VIRUS IS TEMPERATURE SENSITIVE WHEN GROWN IN MOSQUITO C6-36 CELLS

被引：2
|
作者：
LEDGER, TN
SIL, BK
DUNSTER, LM
STEPHENSON, JR
MINOR, PD
BARRETT, ADT
机构：
[1] UNIV SURREY,SCH BIOL SCI,MOLEC MICROBIOL GRP,GUILDFORD GU2 5XH,SURREY,ENGLAND
[2] NATL INST BIOL STAND & CONTROLS,DIV VIROL,POTTERS BAR EN6 3QG,ENGLAND
[3] CTR APPL BACTERIAL METAB & RES,PUBL HLTH LAB SERV,SALISBURY SP4 0JG,ENGLAND
来源：
VACCINE | 1992年 / 10卷 / 10期
关键词：
YELLOW FEVER VIRUS VACCINES; TEMPERATURE SENSITIVITY;
D O I：
10.1016/0264-410X(92)90084-W
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Twenty-three yellow fever (YF) vaccine viruses and three wild-type YF viruses were propagated independently in human adenocarcinoma (SW13) cells and mosquito Aedes albopictus C6-36 cells. The three YF 17DD vaccine viruses were found to be slightly temperature sensitive (ts) at 39.5-degrees-C versus 37.0-degrees-C (efficiency of plaquing 0.04 to 0.1) following propagation in C6-36 but not in SW13 cells. A plaque-purified preparation of the 17DD vaccine manufactured in Brazil was ts when grown in C6-36 cells and remained ts when passaged back into the SW13 cell line.
引用
收藏
页码：652 / 654
页数：3
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