Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint

被引：55

作者：

Silva, P. ^{[1
]}

Barbosa, J. ^{[1
]}

Nascimento, A. V. ^{[1
]}

Faria, J. ^{[1
]}

Reis, R. ^{[1
]}

Bousbaa, H. ^{[1
]}

机构：

[1] CESPU, Inst Super Ciencias Saude Norte, CICS, P-4585116 Gandra Prd, Portugal

来源：

CELL PROLIFERATION | 2011年 / 44卷 / 05期

关键词：

KINETOCHORE-MICROTUBULE INTERACTIONS; SMALL-MOLECULE INHIBITOR; CANCER-CELLS; CYTOPLASMIC DYNEIN; MAD2; ACTIVATION; BI-ORIENTATION; COMPLEX; TENSION; BUBR1; ATTACHMENT;

D O I：

10.1111/j.1365-2184.2011.00767.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accurate chromosome segregation relies on activity of the spindle assembly checkpoint, a surveillance mechanism that prevents premature anaphase onset until all chromosomes are properly attached to the mitotic spindle apparatus and aligned at the metaphase plate. Defects in this mechanism contribute to chromosome instability and aneuploidy, a hallmark of malignant cells. Here, we review the molecular mechanisms of activation and silencing of the spindle assembly checkpoint and its relationship to tumourigenesis.

引用

页码：391 / 400

页数：10

共 50 条

[31] QN1/KIAA1009: a new essential protein for chromosome segregation and mitotic spindle assembly
Leon, A
Omri, B
Gely, A
Klein, C
Crisanti, P
ONCOGENE, 2006, 25 (13) : 1887 - 1895
[32] Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error
Vogt, E.
Kirsich-Volders, M.
Parry, J.
Eichenlaub-Ritter, U.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2008, 651 (1-2) : 14 - 29
[33] Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes
Das, Arunika
Shah, Shital J.
Fan, Bensen
Paik, Daniel
DiSanto, Daniel J.
Hinman, Anna Maria
Cesario, Jeffry M.
Battaglia, Rachel A.
Demos, Nicole
McKim, Kim S.
GENETICS, 2016, 202 (01) : 61 - +
[34] Regulated inactivation of the spindle assembly checkpoint without functional mitotic spindles
De Souza, Colin P.
Hashmi, Shahr B.
Yang, Xiaorui
Osmani, Stephen A.
EMBO JOURNAL, 2011, 30 (13): : 2648 - 2661
[35] Spatial-temporal model for silencing of the mitotic spindle assembly checkpoint
Jing Chen
Jian Liu
Nature Communications, 5
[36] Assessment of the Mitotic Spindle Assembly Checkpoint (SAC) as the Target of Anticancer Therapies
Bolanos-Garcia, Victor M.
CURRENT CANCER DRUG TARGETS, 2009, 9 (02) : 131 - 141
[37] Spatio-Temporal Model for Silencing of the Mitotic Spindle Assembly Checkpoint
Chen, Jing
Liu, Jian
BIOPHYSICAL JOURNAL, 2015, 108 (02) : 451A - 451A
[38] Bub3 Is a Spindle Assembly Checkpoint Protein Regulating Chromosome Segregation during Mouse Oocyte Meiosis
Li, Mo
Li, Sen
Yuan, Ju
Wang, Zhen-Bo
Sun, Shao-Chen
Schatten, Heide
Sun, Qing-Yuan
PLOS ONE, 2009, 4 (11):
[39] Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation
Uchida, Kazuhiko S. K.
Jo, Minji
Nagasaka, Kota
Takahashi, Motoko
Shindo, Norihisa
Shibata, Katsushi
Tanaka, Kozo
Masumoto, Hiroshi
Fukagawa, Tatsuo
Hirota, Toru
CURRENT BIOLOGY, 2021, 31 (08) : 1581 - +
[40] Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis
Shonn, MA
McCarroll, R
Murray, AW
SCIENCE, 2000, 289 (5477) : 300 - 303

← 1 2 3 4 5 →