Single-nucleotide polymorphism in a local population of Trichophyton rubrum

被引：1

作者：

Pchelin, Ivan M. ^{[1
]}

Azarov, Daniil V. ^{[2
]}

Chilina, Galina A. ^{[1
]}

Dmitriev, Kirill A. ^{[1
]}

Vasilyeva, Natalya V. ^{[1
]}

Taraskina, Anastasia E. ^{[1
]}

机构：

[1] North Western State Med Univ, Kashkin Res Inst Med Mycol, St Petersburg, Russia

[2] North Western State Med Univ, Dept Epidemiol Parasitol & Disinfectol, St Petersburg, Russia

来源：

MEDICAL MYCOLOGY | 2018年 / 56卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

epidemiology; NTS typing; SNP; dermatophyte; tinea pedis; NONTRANSCRIBED SPACER; DNA; DIFFERENTIATION; MICROSATELLITES; ONYCHOMYCOSIS;

D O I：

10.1093/mmy/myx009

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Trichophyton rubrum is an important causative agent of superficial mycoses worldwide. To uncover a genetic composition of a local population of this fungus, we sequenced A7C99 6411 and A7C99 6714 loci, coding for hypothetical proteins and revealed two complex genotypes, differing by a single missense mutation in each locus. One of the two A7C99 6411/6714 genotypes was not found in tinea pedis cases and demonstrated mostly longer TRS-1 elements when compared to another genotype. Thus, we present a description of nucleotide polymorphism in protein-coding loci in T. rubrum and provide evidence for ecological preferences of T. rubrum genotypes at a local scale.

引用

页码：125 / 128

页数：4

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