Single-nucleotide polymorphism in a local population of Trichophyton rubrum

被引：1
|
作者：
Pchelin, Ivan M. [1 ]
Azarov, Daniil V. [2 ]
Chilina, Galina A. [1 ]
Dmitriev, Kirill A. [1 ]
Vasilyeva, Natalya V. [1 ]
Taraskina, Anastasia E. [1 ]
机构：
[1] North Western State Med Univ, Kashkin Res Inst Med Mycol, St Petersburg, Russia
[2] North Western State Med Univ, Dept Epidemiol Parasitol & Disinfectol, St Petersburg, Russia
来源：
MEDICAL MYCOLOGY | 2018年 / 56卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
epidemiology; NTS typing; SNP; dermatophyte; tinea pedis; NONTRANSCRIBED SPACER; DNA; DIFFERENTIATION; MICROSATELLITES; ONYCHOMYCOSIS;
D O I：
10.1093/mmy/myx009
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Trichophyton rubrum is an important causative agent of superficial mycoses worldwide. To uncover a genetic composition of a local population of this fungus, we sequenced A7C99 6411 and A7C99 6714 loci, coding for hypothetical proteins and revealed two complex genotypes, differing by a single missense mutation in each locus. One of the two A7C99 6411/6714 genotypes was not found in tinea pedis cases and demonstrated mostly longer TRS-1 elements when compared to another genotype. Thus, we present a description of nucleotide polymorphism in protein-coding loci in T. rubrum and provide evidence for ecological preferences of T. rubrum genotypes at a local scale.
引用
收藏
页码：125 / 128
页数：4
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