Inhibitory effects of Shuanghuanglian injection on nuclear factor-kappa B expression in mice with viral encephalitis in a time- and dose-dependent manner

被引：2
|
作者：
Tian, Ye [1 ]
Han, Caiping [1 ]
Gu, Naibing [1 ]
Di, Zhengli [1 ]
Zhang, Gejuan [1 ]
Lei, Hui [1 ]
机构：
[1] Xian Ctr Hosp, Dept Neurol, Xian 710003, Shaanxi Provinc, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 24期
关键词：
nuclear factor-kappa B; viral encephalitis; mice; gene expression; Shuanghuanglian injection; neural regeneration; GENE-EXPRESSION; SCIATIC-NERVE; MOUSE MODEL; INFECTION; APOPTOSIS; VIRUS; BRAIN; IMMUNOGLOBULIN; DISEASES; THERAPY;
D O I：
10.3969/j.issn.1673-5374.2011.24.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Previous studies have confirmed that the anti-virus effects of Shuanghuanglian injection may be associated with nuclear factor-kappa B activity. This study observed nuclear factor-kappa B expression in mice with viral encephalitis, and showed significant decreases in nuclear factor-kappa B protein and mRNA levels following Shuanghuanglian injection. The inhibitory effect was more significant with prolonged intervention duration and increased treatment dose. These findings verify that Shuanghuanglian injection plays a therapeutic role in viral encephalitis by reducing expression of nuclear factor-kappa B in a time- and dose-dependent manner.
引用
收藏
页码：1865 / 1869
页数：5
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