Inhibitory effects of Shuanghuanglian injection on nuclear factor-kappa B expression in mice with viral encephalitis in a time- and dose-dependent manner

被引：2

作者：

Tian, Ye ^{[1
]}

Han, Caiping ^{[1
]}

Gu, Naibing ^{[1
]}

Di, Zhengli ^{[1
]}

Zhang, Gejuan ^{[1
]}

Lei, Hui ^{[1
]}

机构：

[1] Xian Ctr Hosp, Dept Neurol, Xian 710003, Shaanxi Provinc, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 24期

关键词：

nuclear factor-kappa B; viral encephalitis; mice; gene expression; Shuanghuanglian injection; neural regeneration; GENE-EXPRESSION; SCIATIC-NERVE; MOUSE MODEL; INFECTION; APOPTOSIS; VIRUS; BRAIN; IMMUNOGLOBULIN; DISEASES; THERAPY;

D O I：

10.3969/j.issn.1673-5374.2011.24.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Previous studies have confirmed that the anti-virus effects of Shuanghuanglian injection may be associated with nuclear factor-kappa B activity. This study observed nuclear factor-kappa B expression in mice with viral encephalitis, and showed significant decreases in nuclear factor-kappa B protein and mRNA levels following Shuanghuanglian injection. The inhibitory effect was more significant with prolonged intervention duration and increased treatment dose. These findings verify that Shuanghuanglian injection plays a therapeutic role in viral encephalitis by reducing expression of nuclear factor-kappa B in a time- and dose-dependent manner.

引用

页码：1865 / 1869

页数：5

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